Title: Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore
Authors: Jha, Amitabh ×
Mukherjee, Chandrani
Prasad, Ashok K
Parmar, Virinder S
Vadaparti, Manjula
Das, Umashankar
De Clercq, Erik
Balzarini, Jan
Stables, James P
Shrivastav, Anuraag
Sharma, Rajendra K
Dimmock, Jonathan R #
Issue Date: Mar-2010
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:20 issue:5 pages:1510-5
Abstract: Several series of compounds containing the 1,4-dioxo-2-butenyl moiety have been prepared as candidate cytotoxins, including the methyl N-arylmaleamates, methyl N-arylfumaramates, and N-arylmaleimides. In addition, the N-arylisomaleimides were synthesized which are the structural isomers of N-arylmaleimides. These compounds were evaluated against human Molt 4/C8 and CEM T-lymphocytes as well as murine L1210 cells. Methyl N-arylfumaramates showed the highest cytotoxic potencies and, in particular, methyl N-(3,4-dichlorophenyl)fumaramate is six times more potent than melphalan towards L1210 cells and is equipotent with this drug in the Molt 4/C8 assay. Electrophilicity of compounds under investigation was demonstrated by carrying out thiolation using model benzyl mercaptan on representative compounds. Methyl N-(3,4-dichlorophenyl)fumaramate and methyl N-(4-chlorophenyl)maleamate inhibited human N-myristoyltransferase, a possible molecular target, in high micromolar range. QSAR and molecular modeling revealed some correlations between different structural features of a number of the molecules and cytotoxic potencies. Methyl N-arylfumaramates were well tolerated in mice in comparison to the analogs in other series of compounds tested. The data obtained in this investigation affords guidelines for preparing new series of molecules with greater potencies.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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