Title: Transforming Growth Factor type beta and Smad family signaling in stem cell function
Authors: Seuntjens, Eve ×
Umans, Lieve
Zwijsen, An
Sampaolesi, Maurilio
Verfaillie, Catherine
Huylebroeck, Danny #
Issue Date: Oct-2009
Publisher: Elsevier sci ltd
Series Title: Cytokine & growth factor reviews vol:20 issue:5-6 pages:449-458
Abstract: Ligands of the Transforming Growth Factor type beta (TGF beta) family exert multiple and sometimes opposite effects on most cell types in vivo depending on cellular context, which mainly includes the stage of the target cell, the local environment of this cell or niche, and the identity and the dosage of the ligand. Significant progress has been made in the molecular dissection of the regulation of the activity of the ligands and their intracellular signal transduction pathways, including via the canonical Smad pathway where Smads interact with many transcription factors. This knowledge together with results from functional studies within the embryology and stem cell research fields is giving us insight in the role of individual ligands and other components of this signaling system and where and how it regulates many properties of embryonic and adult stem/progenitor cells, which is anticipated to contribute to successful cell-based therapy in the future.
ISSN: 1359-6101
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Biology (Celgen) (-)
Interdepartemental Stem Cell Institute (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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