Title: Oral administration of beta-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM
Authors: Stuyven, E ×
Verdonck, F
Van Hoek, I
Daminet, S
Duchateau, Luc
Remon, J P
Goddeeris, Bruno
Cox, Eric #
Issue Date: Feb-2010
Publisher: American Society for Microbiology
Series Title: Clinical and Vaccine Immunology vol:17 issue:2 pages:281-285
Abstract: The effect of oral administration of beta-1,3/1,6-glucans from Saccharomyces cerevisiae on humoral immunity in domestic dogs is not known. In this study, 15 beagle dogs were orally given MacroGard tablets, which contain 150 mg of this beta-glucan, daily for 4 weeks. At the end of this period, the total serum immunoglobulin A (IgA) level decreased significantly in the group treated with the glucan compared to that in the control group as well as compared to the concentrations before supplementation. In contrast, the total serum IgM level rose significantly, whereas no effect on the IgG level occurred. Similar changes were seen in Bordetella-specific IgA and IgM titers following vaccination during the supplementation period. The IgA concentration also became significantly lower in the saliva and tears of the glucan group than in the placebo group. The effects disappeared 1 week after the cessation of the supplementation. In conclusion, the results showed a temporary change in the isotype profile during glucan supplementation.
ISSN: 1556-6811
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Gene Technology (-)
Faculty of Science - miscellaneous
× corresponding author
# (joint) last author

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