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Title: Conjunctival effects of a selective nasal pollen provocation
Authors: Callebaut, Ina ×
Spielberg, L
Hox, Valérie
Bobic, Sonja
Jorissen, Mark
Stalmans, Ingeborg
Scadding, G
Ceuppens, Jan
Hellings, Peter #
Issue Date: Sep-2010
Publisher: Munksgaard
Series Title: Allergy vol:65 issue:9 pages:1173-1181
Abstract: BACKGROUND:

Several clinical and experimental observations suggest that allergen deposition in the nose may partially be responsible for the induction of conjunctival symptoms in allergic rhinitis. The aims of this study were to evaluate the induction of conjunctival symptoms by selective nasal allergen provocation and to assess the feasibility of the different tools for evaluation of conjunctival allergic inflammation.

METHODS:

Grass pollen allergic subjects with rhinoconjunctivitis symptoms during the pollen season (n = 12) underwent a nasal sham and grass pollen provocation extra-seasonally. Nasal and conjunctival symptoms were scored using the Visual Analogue Scale (VAS) system at baseline, 15 min, 1 h and 24 h after provocation. In addition to Peak Nasal Inspiratory flow (PNIF) measurements, conjunctival inflammation and vascular congestion were evaluated and histamine and substance P levels in tear fluid were measured.

RESULTS:

Selective nasal grass pollen provocation induced ocular pruritus, lacrimation and conjunctival vascular congestion. PNIF values correlated inversely with lacrimation (r = -0.71, P < 0.001) and ocular pruritus (r = -0.41, P < 0.05). Four out of 11 patients showed a conjunctival eosinophilic inflammation and levels of histamine (r = 0.73, P < 0.05) and substance P (r = 0.67, P = 0.05) in tear fluid correlated with conjunctival symptoms.

CONCLUSION:

Selective nasal grass pollen provocation induced conjunctival inflammation, ocular pruritus and lacrimation, which correlated with histamine and substance P levels in tear fluid and inversely with the PNIF values. These data show a naso-ocular interaction in allergic rhinitis and offer objective tools for evaluation of conjunctival inflammation in allergic rhinoconjunctivitis.
ISSN: 0105-4538
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical Immunology
Department of Experimental Medicine (-)
Research Group Experimental Oto-rhino-laryngology
Research Group Ophthalmology
Department of Microbiology & Immunology - miscellaneous
× corresponding author
# (joint) last author

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