A case of fibrolipoma of the median nerve was described. Peripheral nerve tumors of the upper extremity are very rare. Within this group of tumors, the fibrolipoma is an exceedingly uncommon entity. It was first described in 1953, and to date less than 100 cases have been described. The purpose of this report was to point out a characteristic sign of fibrolipoma, which in our opinion allows distinction on CT and MRI between fibrolipoma and the other peripheral nerve and fatty soft tissue tumors.