Title: Cytotoxicity of natural compounds isolated from the seeds of Garcinia afzelii
Authors: Lannang, Alain Meli ×
Louh, Gabin Nselapi
Biloa, Bernadette Messi
Komguem, Justin
Mbazoa, Celine Djama
Sondengam, Beiban Luc
Naesens, Lieve
Pannecouque, Christophe
De Clercq, Erik
Sayed El Ashry, El H #
Issue Date: May-2010
Publisher: Georg Thieme Verlag
Series Title: Planta Medica vol:76 issue:7 pages:708-12
Abstract: The new compounds guttiferone O ( 1) and 3-methoxycheffouxanthone ( 2) have been isolated from the seeds of Garcinia afzelii Engl., together with nine known compounds: 2-hydroxy-1,7-dimethoxyxanthone ( 3), smeathxanthone A ( 4), 1,5-dihydroxyxanthone ( 5), 1,6-dihydroxy-5-methoxyxanthone ( 6), cheffouxanthone ( 7), 1,3,5-trihydroxyxanthone ( 8), smeathxanthone B ( 9), isoxanthochymol ( 10) and guttiferone E ( 11). Their structures were elucidated by means of 1D and 2D-NMR techniques. All the isolates showed high cytotoxic activity and were found inactive when tested against HIV and influenza viruses.
ISSN: 0032-0943
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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