ITEM METADATA RECORD
Title: Towards a molecular description of intermediate filament structure and assembly
Authors: Parry, David A D *
Strelkov, Sergei *
Burkhard, Peter
Aebi, Ueli
Herrmann, Harald # ×
Issue Date: Jun-2007
Series Title: Experimental cell research vol:313 issue:10 pages:2204-16
Abstract: Intermediate filaments (IFs) represent one of the prominent cytoskeletal elements of metazoan cells. Their constituent proteins are coded by a multigene family, whose members are expressed in complex patterns that are controlled by developmental programs of differentiation. Hence, IF proteins found in epidermis differ significantly from those in muscle or neuronal tissues. Due to their fibrous nature, which stems from a fairly conserved central alpha-helical coiled-coil rod domain, IF proteins have long resisted crystallization and thus determination of their atomic structure. Since they represent the primary structural elements that determine the shape of the nucleus and the cell more generally, a major challenge is to arrive at a more rational understanding of how their nanomechanical properties effect the stability and plasticity of cells and tissues. Here, we review recent structural results of the coiled-coil dimer, assembly intermediates and growing filaments that have been obtained by a hybrid methods approach involving a rigorous combination of X-ray crystallography, small angle X-ray scattering, cryo-electron tomography, computational analysis and molecular modeling.
URI: 
ISSN: 0014-4827
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biocrystallography
* (joint) first author
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
parry_strelkov_ecr2007[1].pdf Published 1855KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science