Title: Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome
Authors: Van Mieghem, Tim ×
Doné, Elisa
Gucciardo, LĂ©onardo
Klaritsch, Philipp
Allegaert, Karel
Van Bree, Rita
Lewi, Liesbeth
Deprest, Jan #
Issue Date: Jan-2010
Publisher: Mosby, Inc.
Series Title: American Journal of Obstetrics and Gynecology vol:202 issue:1 pages:48.e1-48.e7
Article number: 48.e1
Abstract: OBJECTIVE: The objective of the study was to determine whether cardiac troponin T (cTnT) and natriuretic peptides can be isolated from the amniotic fluid (AF) of pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) and whether they correlate with fetal echocardiographic findings and recipient survival. STUDY DESIGN: AF samples from the recipient sac were obtained in 52 TTTS cases and 16 controls. Samples were assayed for cTnT and natriuretic peptides. Prior to fetoscopic laser therapy, 34 recipient twins underwent assessment of atrioventricular flow patterns, myocardial performance index (MPI), and precordial venous Dopplers. Fetal survival was assessed 48 hours postoperatively. RESULTS: AF B-type natriuretic peptide and cTnT levels were elevated in TTTS and correlated with functional echocardiographic findings. Postoperative recipient survival was 72% when both AF-cTnT and left ventricular MPI were increased. If 1 of both markers was normal, survival was 100% (P = .046). CONCLUSION: Combining ultrasound and AF-cTnT measurements allows the identification of fetuses at risk of postoperative demise.
ISSN: 0002-9378
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Foetal Medicine Section (-)
Section Woman - Miscellaneous (-)
Section Newborn (-)
Organ Systems (+)
× corresponding author
# (joint) last author

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