Title: Has the Prevalence of Congenital Abnormalities after Intracytoplasmic Sperm Injection Increased? The Leuven Data 1994-2000 and a Review of the Literature
Authors: Hindryckx, An
Peeraer, Karen
Debrock, Sophie
Legius, Eric
de Zegher, Francis
Francois, Inge
Vanderschueren, Dirk
Demyttenaere, Koen
Rijkers, Anna
D'Hooghe, Thomas # ×
Issue Date: Jan-2010
Series Title: Gynecologic and obstetric investigation vol:70 issue:1 pages:11-22
Abstract: Background: Although intracytoplasmic sperm injection (ICSI) is now accepted as the treatment of choice for severe male infertility, concerns about its safety and the potential risks for the offspring remain. We reviewed the literature with respect to the prevalence of major congenital malformations after the ICSI technique and supplemented these data with the results of a prospective follow-up study performed in our center. Methods: From January 1994 till June 2000, 776 ICSI cycles were carried out at the Leuven University Fertility Center. The resulting pregnancies (n = 172) were followed for biochemical and obstetrical parameters, prenatal diagnosis and congenital abnormalities. Results: A total of 134/172 (78%) ongoing pregnancies resulted in 132 deliveries of 166 live born children. Two terminations of pregnancy were carried out due to the presence of major congenital anomalies, diagnosed at prenatal ultrasound. Prenatal diagnosis was carried out in 55 fetuses. Two de novo chromosomal aberrations were found. Major congenital abnormalities were observed at birth in 9/150 (6.0%) children. The total malformation rate was 6.5%. Conclusions: The prevalence of congenital abnormalities in children born after ICSI in our center (6.5%) was comparable to the prevalence of congenital abnormalities after ICSI reported in the literature.
ISSN: 0378-7346
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Section Woman - Miscellaneous (-)
Section Newborn (-)
Pediatric Hematology & Oncology Section (-)
Clinical and Experimental Endocrinology
Research Group Psychiatry
Assisted Reproductive Technology Laboratory (-)
× corresponding author
# (joint) last author

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