Title: Deep brain stimulation modulates effects of motivation in Parkinson's disease
Authors: Sauleau, Paul ×
Eusebio, Alexandre
Vandenberghe, Wim
Nuttin, Bart
Brown, Peter #
Issue Date: 22-Apr-2009
Publisher: Rapid Communications of Oxford Ltd.
Series Title: Neuroreport vol:20 issue:6 pages:622-6
Abstract: It is unclear how motivation leads to improved motor performance. Here we test the hypothesis that motivation interacts with behavioural performance in the basal ganglia. We recorded trial-to-trial performance in a bimanual motor task in 10 patients with Parkinson's disease with electrodes chronically implanted in the subthalamic nucleus for deep brain stimulation. Motivation-associated improvements in trial-to-trial performance were contrasted with and without stimulation at high frequency. Motivation and stimulation improved trial-to-trial performance, but the effect of motivation was halved during stimulation. We conclude that the subthalamic area is mechanistically important in those processes linking motivation to improvement in motor performance. This finding may be relevant to some of the cognitive and emotional changes associated with bilateral subthalamic stimulation.
ISSN: 0959-4965
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Research Group Experimental Neurosurgery and Neuroanatomy
Laboratory for Parkinson Research
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science