Title: Inhibition of enzymatic degradation of adhesive-dentin interfaces
Authors: De Munck, Jan ×
Van den Steen, Philippe
Mine, Atsushi
Van Landuyt, Kirsten
Poitevin, André
Opdenakker, Ghislain
Van Meerbeek, Bart #
Issue Date: Dec-2009
Publisher: Sage publications inc
Series Title: Journal of Dental Research vol:88 issue:12 pages:1101-1106
Abstract: Adhesive procedures activate dentin-associated matrix metalloproteinases (MMPs), and so iatrogenically initiate bond degradation. We hypothesized that adding MMP inhibitors to adhesive primers may prevent this endogenous enzymatic degradation, thereby improving bond durability. A nonspecific MMP inhibitor (chlorhexidine) and a MMP-2/9-specific inhibitor (SB-3CT) were admixed to the primers of an etch & rinse and a self-etch adhesive, both considered as gold-standard adhesives within their respective categories. For dentin powder exposed to the adhesives under clinical application conditions, gelatin zymography revealed the release of MMP-2 (not of MMP-9) by the etch & rinse adhesive, while no release of enzymes could be detected for the mild self-etch adhesive, most likely because of its limited dentin demineralization effect. The built-in MMP inhibitors appeared effective in reducing bond degradation only for the etch & rinse adhesive, and not for the self-etch adhesive. Water sorption of adhesive interfaces most likely remains the principal mechanism of bond degradation, while endogenous enzymes appear to contribute to bond degradation of only etch & rinse adhesives.
ISSN: 0022-0345
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Residents Dentistry
Department of Oral Health Sciences - miscellaneous
Laboratory of Immunobiology (Rega Institute)
Biomaterials - BIOMAT
× corresponding author
# (joint) last author

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