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Title: Laboratory diagnosis of specific antibody deficiency to pneumococcal polysaccharide antigens by multiplexed bead assay
Authors: Borgers, Heleen
Moens, Leen
Picard, Capucine
Jeurissen, Axel
Raes, Marc
Sauer, Kate
Proesmans, Marijke
De Boeck, Christiane
Casanova, Jean-Laurent
Meyts, Isabelle
Bossuyt, Xavier # ×
Issue Date: Feb-2010
Publisher: Academic Press
Series Title: Clinical Immunology vol:134 issue:2 pages:198-205
Abstract: We evaluated a multiplexed bead-based assay (xMAP Pneumococcal Immunity assay from Luminex) for the simultaneous determination of antibodies against 14 capsular polysaccharides. Post-vaccination (Pneumovax) antibody concentrations were measured in 35 healthy children, 40 healthy adults, 99 consecutive patients with increased susceptibility to respiratory infection, and 24 patients with a deficient anti-polysaccharide antibody response. The serotype-specific lower 5th percentile (cutoff) value for the post-immunization antibody concentration was determined in healthy individuals. Eleven of 99 patients (11%) failed to mount a response that was >5th percentile of controls for at least 6 of the 14 serotypes tested, whereas only 3 of 75 controls (4%) failed to do so. All patients with known anti-polysaccharide antibody deficiency failed to mount a response that was >5th percentile of controls for at least 6 of the 14 serotypes tested. The XMAP pneumococcal immunity panel appears useful for identifying individuals with a low response to the unconjugated pneumococcal vaccine.
ISSN: 1521-6616
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pediatric Pulmonology Section (-)
Section Child - Miscellaneous (-)
Laboratory of Pediatric Immunology
Laboratory of Clinical Bacteriology and Mycology
Experimental Laboratory Immunology
× corresponding author
# (joint) last author

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