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Title: Evidence for nitric oxide as mediator of non-adrenergic non-cholinergic relaxations induced by ATP and GABA in the canine gut
Authors: Boeckxstaens, Guy ×
Pelckmans, PA
Bult, H
De Man, JG
Herman, AG
Van Maercke, YM #
Issue Date: Feb-1991
Publisher: Scientific & Medical Division, Macmillan Press
Stockton press
Series Title: British journal of pharmacology vol:102 issue:2 pages:434-438
Abstract: 1 The effects of haemoglobin, and the nitric oxide (NO) biosynthesis-inhibitors N(G)-monomethyl-L-arginine (L-NMMA), its enantiomer D-NMMA, and N(G)-nitro-L-arginine (L-NNA) were investigated on non-adrenergic non-cholinergic (NANC)-mediated relaxation of circular muscle strips of the canine terminal ileum and ileocolonic junction induced by electrical stimulation, adenosine 5'-triphosphate (ATP), gamma-aminobutyric acid (GABA) and NO. 2 Tetrodotoxin, L-NMMA and L-NNA, but not D-NMMA, inhibited the relaxations induced by electrical stimulation, ATP and GABA, but not those in response to NO. 3 The inhibitory effect of L-NMMA and L-NNA was prevented by L-arginine, but not by D-arginine. L-Arginine did not potentiate any of the NANC relaxations. 4 Haemoglobin reduced the relaxation induced by electrical stimulation, ATP and GABA, and abolished those in response to NO. 5 Our results demonstrate that the ATP- and GABA-induced relaxations resulting from stimulation of intramural NANC neurones, in addition to those induced by electrical impulses, are mediated by NO or a NO releasing substance and thus provide further evidence in support of the proposal that NO is the final inhibitory NANC neurotransmitter in the canine terminal ileum and ileocolonic junction.
ISSN: 0007-1188
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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