Title: The why and how of thymocyte negative selection
Authors: Siggs, O M
Makaroff, L E
Liston, Adrian # ×
Issue Date: Apr-2006
Publisher: Current Science
Series Title: Current Opinion in Immunology vol:18 issue:2 pages:175-183
Abstract: The generation of T cell receptor (TCR) sequence diversity is the strength of adaptive immunity, yet is also the Achilles' heel. To purge highly self-reactive T cells from the immune system, generation of diversity has coevolved with a mechanism of negative selection. Recent studies have revealed new insights addressing the why and how of negative selection by examining situations in which negative selection has failed in human and animals models of autoimmunity. Both thymocyte extrinsic and intrinsic mechanisms are required to restrict the TCR repertoire to a non-autoreactive set. Negative selection also ensures that T cells emerge with receptors that are focussed on the peptide moiety of MHC-peptide complexes.
ISSN: 0952-7915
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Experimental Medicine (-)
Laboratory of Genetics of Autoimmunity
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
2006_Liston, The why and how of thymocite negative selection.pdf Submitted 371KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science