Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling
Liston, Adrian Hardy, Kristine Pittelkow, Yvonne Wilson, Susan R Makaroff, Lydia E Fahrer, Aude M Goodnow, Christopher C # ×
BioMed Central Ltd.
Genome Biology vol:8 issue:1 pages:1-23
Background: T cells in the thymus undergo opposing positive and negative selection processes so that the only T cells entering circulation are those bearing a T cell receptor (TCR) with a low affinity for self. The mechanism differentiating negative from positive selection is poorly understood, despite the fact that inherited defects in negative selection underlie organ-specific autoimmune disease in AIRE-deficient people and the non-obese diabetic (NOD) mouse strain.