Title: Generalized resistance to thymic deletion in the NOD mouse: A polygenic trait characterized by defective induction of Bim
Authors: Liston, Adrian
Lesage, S
Gray, DHD
O'Reilly, LA
Strasser, A
Fahrer, AM
Boyd, RL
Wilson, J
Baxter, AG
Gallo, EM
Crabtree, GR
Peng, KM
Wilson, SR
Goodnow, CC # ×
Issue Date: Dec-2004
Publisher: Cell press
Series Title: Immunity vol:21 issue:6 pages:817-830
Abstract: The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7,rnit101, and D15mit229 which cause a generalized resistance to thymic deletion in vivo that applies equally to Aire-induced organ-specific gene products in the thymic medulla and to systemic antigens expressed at high levels throughout the thymus and affects CD4(+).
ISSN: 1074-7613
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Experimental Medicine (-)
Laboratory of Genetics of Autoimmunity
× corresponding author
# (joint) last author

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