Generalized resistance to thymic deletion in the NOD mouse: A polygenic trait characterized by defective induction of Bim
Liston, Adrian Lesage, S Gray, DHD O'Reilly, LA Strasser, A Fahrer, AM Boyd, RL Wilson, J Baxter, AG Gallo, EM Crabtree, GR Peng, KM Wilson, SR Goodnow, CC # ×
Immunity vol:21 issue:6 pages:817-830
The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7,rnit101, and D15mit229 which cause a generalized resistance to thymic deletion in vivo that applies equally to Aire-induced organ-specific gene products in the thymic medulla and to systemic antigens expressed at high levels throughout the thymus and affects CD4(+).