The role of nitric-oxide in inhibitory nonadrenergic noncholinergic neurotransmission in the canine lower esophageal sphincter
Deman, Jg × Pelckmans, Pa Boeckxstaens, Guy Bult, H Oosterbosch, L Herman, Ag Vanmaercke, Ym #
British journal of pharmacology vol:103 issue:1 pages:1092-1096
1 The role of nitric oxide (NO) in non-adrenergic non-cholinergic (NANC) neurotransmission was studied on circular muscle strips of the canine lower oesophageal sphincter (LOS). Electrical field stimulation evoked frequency-dependent relaxations, which were resistant to adrenergic and cholinergic blockade and abolished by tetrodotoxin.