Title: Pharmacological similarity between nitric oxide and the nitrergic neurotransmitter in the canine ileocolonic junction
Authors: Boeckxstaens, Guy ×
De Man, J G
De Winter, B Y
Herman, A G
Pelckmans, P A #
Issue Date: Oct-1994
Series Title: European journal of pharmacology vol:264 issue:1 pages:85-9
Abstract: In organ bath experiments, pyrogallol (30-100 microM), and to a lesser extent L-cysteine (3 microM), reduced nitric oxide (NO)-induced relaxation, but not the NO-mediated non-adrenergic non-cholinergic (NANC) relaxation elicited by field stimulation of the canine ileocolonic junction. In contrast, in a superfusion bioassay, pyrogallol (10-30 microM) and L-cysteine (1 microM) inhibited the biological activity of both the transferable nitrergic factor released from the canine ileocolonic junction in response to NANC nerve stimulation and NO, but not that of S-nitroso-L-cysteine, S-nitrosoglutathione or S-nitroso-N-acetyl-D,L-penicillamine. Based on the bioassay experiments, it is concluded that the nitrergic NANC neurotransmitter in the canine ileocolonic junction behaves pharmacologically like NO.
ISSN: 0014-2999
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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