Author:

Keywords:

ileus, motilin, cisapride, metoclopramide, 5-ht3 receptor, 5-ht4 receptor, clinical-application, double-blind, in-vivo, erythromycin, receptor, motility, pharmacology, transit, Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, 5-HT3 receptor, 5-HT4 receptor, CLINICAL-APPLICATION, DOUBLE-BLIND, IN-VIVO, ERYTHROMYCIN, CISAPRIDE, RECEPTOR, MOTILITY, METOCLOPRAMIDE, PHARMACOLOGY, TRANSIT, Animals, Cisapride, Dopamine Antagonists, Erythromycin, Gastrointestinal Agents, Granisetron, Intestinal Obstruction, Male, Metoclopramide, Postoperative Complications, Random Allocation, Rats, Rats, Wistar, Serotonin Antagonists, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 3202 Clinical sciences, 3210 Nutrition and dietetics

Abstract:

Background/Aim-The effects of different prokinetic agents, the motilide erythromycin and the substituted benzamides metoclopramide and cisapride, were investigated in a rat model of postoperative ileus. These effects were compared with that of granisetron, a 5-hydroxytryptamine (5-HT3) receptor antagonist, and a novel enterokinetic agent, prucalopride, a 5-HT4 receptor agonist.