Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats
De Winter, BY × Boeckxstaens, Guy De Man, JG Moreels, TG Schuurkes, JAJ Peeters, TL Herman, AG Pelckmans, PA #
British med journal publ group
Gut vol:45 issue:5 pages:713-718
Background/Aim-The effects of different prokinetic agents, the motilide erythromycin and the substituted benzamides metoclopramide and cisapride, were investigated in a rat model of postoperative ileus. These effects were compared with that of granisetron, a 5-hydroxytryptamine (5-HT3) receptor antagonist, and a novel enterokinetic agent, prucalopride, a 5-HT4 receptor agonist.