Author:

Keywords:

gastric fundus, gastrointestinal motility, ileus, nitric oxide, non-adrenergic non-cholinergic, vasoactive intestinal polypeptide, nonadrenergic noncholinergic nerves, postoperative gastric ileus, nitric-oxide, reflex relaxation, release, involvement, capsaicin, cat, vip, Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, VASOACTIVE INTESTINAL POLYPEPTIDE, NONADRENERGIC NONCHOLINERGIC NERVES, POSTOPERATIVE GASTRIC ILEUS, NITRIC-OXIDE, REFLEX RELAXATION, RELEASE, INVOLVEMENT, CAPSAICIN, CAT, VIP, Abdomen, Afferent Pathways, Animals, Gastric Fundus, Guanethidine, Male, Muscle Relaxation, Neural Inhibition, Nitric Oxide, Nitroarginine, Rats, Rats, Sprague-Dawley, Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Receptors, Pituitary Hormone, Receptors, Vasoactive Intestinal Peptide, Receptors, Vasoactive Intestinal Polypeptide, Type I, 1115 Pharmacology and Pharmaceutical Sciences, 3214 Pharmacology and pharmaceutical sciences

Abstract:

1 We previously reported activation of an inhibitory adrenergic and a non-adrenergic noncholinergic (NANC) pathway during abdominal surgery relaxing the rat gastric fundus. In the present study, we investigated the possible role of nitric oxide (NO) and vasoactive intestinal polypeptide (VIP) in the NANC part of the surgery-induced fundic relaxation.