A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European organization for research and treatment of cancer (EORTC) study 22844
Karim, ABMF × Maat, B Hatlevoll, R Menten, Johan Rutten, EHJM Thomas, DGT Mascarenhas, F Horiot, JC Parvinen, LM vanReijn, M Hamers, HP Gaspar, L Noordman, E Pierart, M vanGlabbeke, M vanAlphen, AM Jager, JJ Fabrini, MG #
Pergamon-elsevier science ltd
International journal of radiation oncology biology physics vol:36 issue:3 pages:549-556
Purpose: Cerebral low-grade gliomas (LGG) in adults are mostly composed of astrocytomas, oligodendrogliomas, and mixed oligoastrocytomas. There is at present no consensus in the policy of treatment of these tumors. We sought to determine the efficacy of radiotherapy and the presence of a dose-response relationship for these tumors in two multicentric randomized trials conducted by the European Organization for Research and Treatment of Cancer (EORTC). The dose-response study is the subject of this article.