Title: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
Authors: Stupp, R
Mason, WP
van den Bent, MJ
Weller, M
Fisher, B
Taphoorn, MJB
Belanger, K
Brandes, AA
Marosi, C
Bogdahn, U
Curschmann, J
Hofer, S
Pesce, G
Curschmann, J
Dietrich, PY
Stupp, R ×
Mirimanoff, RO
Thum, P
Baumert, B
Ryan, G
Janzer, RC
Ludwin, SK
Gorlia, T
Allgeier, A
Lacombe, D
Cairncross, JG
Eisenhauer, E
Mirimanoff, RO
Van Den Weyngaert, D
Kaendler, S
Krauseneck, P
Vinolas, N
Villa, S
Wurm, RE
Maillot, MHB
Spagnolli, F
Kantor, G
Malhaire, JP
Renard, L
De Witte, O
Scandolaro, L
Vecht, CJ
Maingon, P
Lutterbach, J
Kobierska, A
Bolla, M
Souchon, R
Mitine, C
Tzuk-Shina, T
Kuten, A
Haferkamp, G
de Greve, J
Priou, F
Menten, Johan
Rutten, I
Clavere, P
Malmstrom, A
Jancar, B
Newlands, E
Pigott, K
Twijnstra, A
Chinot, O
Reni, M
Boiardi, A
Fabbro, M
Campone, M
Bozzino, J
Frenay, M
Gijtenbeek, J
Brandes, AA
Delattre, JY
Bogdahn, U
De Paula, U
van den Bent, MJ
Hanzen, C
Pavanato, G
Schraub, S
Pfeffer, R
Soffietti, R
Weller, M
Kortmann, RD
Taphoorn, M
Torrecilla, JL
Marosi, C
Grisold, W
Huget, P
Forsyth, P
Fulton, D
Kirby, S
Wong, R
Fenton, D
Fisher, B
Cairncross, G
Whitlock, P
Belanger, K
Burdette-Radoux, S
Gertler, S
Saunders, S
Laing, K
Siddiqui, J
Martin, LA
Gulavita, S
Perry, J
Mason, W
Thiessen, B
Pai, H
Alam, ZY
Eisenstat, D
Mingrone, W #
Issue Date: Mar-2005
Series Title: New England Journal of Medicine vol:352 issue:10 pages:987-996
Abstract: BACKGROUND: Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by adjuvant radiotherapy. In this trial we compared radiotherapy alone with radiotherapy plus temozolomide, given concomitantly with and after radiotherapy, in terms of efficacy and safety. METHODS: Patients with newly diagnosed, histologically confirmed glioblastoma were randomly assigned to receive radiotherapy alone (fractionated focal irradiation in daily fractions of 2 Gy given 5 days per week for 6 weeks, for a total of 60 Gy) or radiotherapy plus continuous daily temozolomide (75 mg per square meter of body-surface area per day, 7 days per week from the first to the last day of radiotherapy), followed by six cycles of adjuvant temozolomide (150 to 200 mg per square meter for 5 days during each 28-day cycle). The primary end point was overall survival. RESULTS: A total of 573 patients from 85 centers underwent randomization. The median age was 56 years, and 84 percent of patients had undergone debulking surgery. At a median follow-up of 28 months, the median survival was 14.6 months with radiotherapy plus temozolomide and 12.1 months with radiotherapy alone. The unadjusted hazard ratio for death in the radiotherapy-plus-temozolomide group was 0.63 (95 percent confidence interval, 0.52 to 0.75; P<0.001 by the log-rank test). The two-year survival rate was 26.5 percent with radiotherapy plus temozolomide and 10.4 percent with radiotherapy alone. Concomitant treatment with radiotherapy plus temozolomide resulted in grade 3 or 4 hematologic toxic effects in 7 percent of patients. CONCLUSIONS: The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity. Copyright 2005 Massachusetts Medical Society.
ISSN: 0028-4793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Radiotherapy
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science