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Title: Quality of life after radiation therapy of cerebral low-grade gliomas of the adult: Results of a randomised phase III trial on dose response (EORTC trial 22844)
Authors: Kiebert, GM ×
Curran, D
Aaronson, NK
Bolla, M
Menten, Johan
Rutten, EHJM
Nordman, E
Silvestre, ME
Pierart, M
Karim, ABMF #
Issue Date: Nov-1998
Publisher: Pergamon-elsevier science ltd
Series Title: European journal of cancer vol:34 issue:12 pages:1902-1909
Abstract: In 1985, the EORTC Radiotherapy Go-operative Group launched a randomised phase III study comparing high-dose (59.4 Gy in 6.5 weeks) versus law-dose (45 Gy in 5 weeks) radiotherapy with conventional techniques in patients diagnosed with low-grade cerebral glioma. The primary endpoint of the study was survival. No difference in survival was observed between the two treatment strategies, A quality of Life (QoL) questionnaire consisting of 47 items assessing a range of physical, psychological, social, and symptom domains was included in the trial to measure the impact of treatment over time. Patients who received high-dose radiotherapy tended to report lower levels of functioning and more symptom burden following completion of radiotherapy. These group differences were statistically significant for fatigue/malaise and insomnia immediately after radiotherapy and in leisure time and emotional functioning at 7-15 months after randomisation. These findings suggest that: for conventional radiotherapy for low-grade cerebral glioma, a schedule of 45 Gy in 5 weeks not only saves valuable resources, but also spares patients a prolonged treatment at no loss of clinical efficacy. (C) 1998 Elsevier Science Ltd. All rights reserved.
URI: 
ISSN: 0959-8049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Radiotherapy
× corresponding author
# (joint) last author

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