Title: Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
Authors: de Jonge, WJ ×
van der Zanden, EP
O The, F
Bijlsma, MF
van Westerloo, DJ
Bennink, RJ
Berthoud, HR
Uematsu, S
Akira, S
van den Wijngaard, RM
Boeckxstaens, Guy #
Issue Date: Aug-2005
Publisher: Nature publishing group
Series Title: Nature immunology vol:6 issue:8 pages:844-851
Abstract: Acetylcholine released by efferent vagus nerves inhibits macrophage activation. Here we show that the anti-inflammatory action of nicotinic receptor activation in peritoneal macrophages was associated with activation of the transcription factor STAT3. STAT3 was phosphorylated by the tyrosine kinase Jak2 that was recruited to the alpha 7 subunit of the nicotinic acetylcholine receptor. The anti-inflammatory effect of nicotine required the ability of phosphorylated STAT3 to bind and transactivate its DNA response elements. In a mouse model of intestinal manipulation, stimulation of the vagus nerve ameliorated surgery-induced inflammation and postoperative ileus by activating STAT3 in intestinal macrophages. We conclude that the vagal antiinflammatory pathway acts by alpha 7 subunit-mediated Jak2-STAT3 activation.
ISSN: 1529-2908
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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