The role of GABA(A) receptors in the control of transient lower oesophageal sphincter relaxations in the dog
Beaumont, H × Jonsson-Rylander, A-C Carlsson, K Pierrou, S Ahlefelt, M Branden, L Jensen, J Boeckxstaens, Guy Lehmann, A #
Nature publishing group
British journal of pharmacology vol:153 issue:6 pages:1195-1202
Background and purpose: Transient lower oesophageal sphincter relaxations (TLESRs) are triggered by activation of mechanosensitive gastric vagal afferents and are the major cause of gastroesophageal reflux and therefore an important target for therapeutic intervention in gastroesophageal reflux disease (GERD). Activation of the metabotropic GABA(B) receptor has shown to inhibit TLESRs. The aim of the present study was to assess the role of the ionotropic GABA(A) receptor in the regulation of TLESRs.