The Role of Mast Cell Stabilization in Treatment of Postoperative Ileus: A Pilot Study
The, Frans O × Buist, Marrije R Lei, Aaltje Bennink, Roelof J Hofland, Jan van den Wijngaard, Rene M de Jonge, Wouter J Boeckxstaens, Guy #
Nature publishing group
American journal of gastroenterology vol:104 issue:9 pages:2257-2266
OBJECTIVES: Although postoperative ileus (POI) is considered multifactorial, intestinal inflammation resulting from manipulation-induced mast cell activation is recognized as an important pathophysiological mechanism. Therefore, mast cell stabilization may represent a new therapeutic approach to shortening POI. The aim of this paper was to study the effect of ketotifen, a mast cell stabilizer, on postoperative gastrointestinal transit in patients who underwent abdominal surgery.