Title: Synthesis and lipase-catalysed enantioselective acylation studies on ethyl 4-aryl-3,4-dihydropyrimidin-2(1H)-ones
Authors: Prasad, Ashok K ×
Arya, Pragya
Bhatia, Sumati
Sharma, Raman K
Singh, Rishipal
Singh, Brajendra K
Van der Eycken, Erik
Singh, Rajpal
Olsen, Carl E
Parmar, Virinder S #
Issue Date: Dec-2009
Publisher: Published by the Council of Scientific & Industrial Research in Association with the Indian National Science Academy
Series Title: Indian Journal of Chemistry B, Organic Including Medicinal vol:48 issue:12 pages:1738-1748
Abstract: A series of different analogs of 4-aryl-3,4-dihydropyrimidin-2(1H)-one have been synthesized and their biocatalytic resolution has been carried out using immobilized lipase CAL-L(A) (immobilized on accurel). The systematic one-step procedure is developed for the synthesis of optically enriched ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates 8a-d and acylated ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates 9a-e, 10a-e, 11b-d and 12a-e, by the enantioselective acylation of racemic ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates using CAL-L(A).
ISSN: 0376-4699
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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