Synthesis and lipase-catalysed enantioselective acylation studies on ethyl 4-aryl-3,4-dihydropyrimidin-2(1H)-ones
Prasad, Ashok K × Arya, Pragya Bhatia, Sumati Sharma, Raman K Singh, Rishipal Singh, Brajendra K Van der Eycken, Erik Singh, Rajpal Olsen, Carl E Parmar, Virinder S #
Published by the Council of Scientific & Industrial Research in Association with the Indian National Science Academy
Indian Journal of Chemistry B, Organic Including Medicinal vol:48 issue:12 pages:1738-1748
A series of different analogs of 4-aryl-3,4-dihydropyrimidin-2(1H)-one have been synthesized and their biocatalytic resolution has been carried out using immobilized lipase CAL-L(A) (immobilized on accurel). The systematic one-step procedure is developed for the synthesis of optically enriched ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates 8a-d and acylated ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates 9a-e, 10a-e, 11b-d and 12a-e, by the enantioselective acylation of racemic ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates using CAL-L(A).