Title: Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin
Authors: Coremans, Vanessa
Ahmed, Tariz
Balschun, Detlef
D'Hooge, Rudi
De Vriese, Astrid
Cremer, Jonathan
Antonucci, Flavia
Moons, Michael
Baekelandt, Veerle
Reumers, Veerle
Cremer, Harold
Eisch, Amelia
Lagace, Diane
Janssens, Tom
Bozzi, Yuri
Caleo, Matteo
Conway, Edward # ×
Issue Date: Jan-2010
Publisher: BioMed Central
Series Title: BMC Neuroscience vol:11 pages:1-19
Article number: 2
Abstract: ABSTRACT: BACKGROUND: Survivin is a unique member of the inhibitor of apoptosis protein (IAP) family in that it exhibits antiapoptotic properties and also promotes the cell cycle and mediates mitosis as a chromosome passenger protein. Survivin is highly expressed in neural precursor cells in the brain, yet its function there has not been elucidated. RESULTS: To examine the role of neural precursor cell survivin, we first showed that survivin is normally expressed in periventricular neurogenic regions in the embryo, becoming restricted postnatally to proliferating and migrating NPCs in the key neurogenic sites, the subventricular zone (SVZ) and the subgranular zone (SGZ). We then used a conditional gene inactivation strategy to delete the survivin gene prenatally in those neurogenic regions. Lack of embryonic NPC survivin results in viable, fertile mice (SurvivinCamcre) with reduced numbers of SVZ NPCs, absent rostral migratory stream, and olfactory bulb hypoplasia. The phenotype can be partially rescued, as intracerebroventricular gene delivery of survivin during embryonic development increases olfactory bulb neurogenesis, detected postnatally. SurvivinCamcre brains have fewer cortical inhibitory interneurons, contributing to enhanced sensitivity to seizures, and profound deficits in memory and learning. CONCLUSIONS: The findings highlight the critical role that survivin plays during neural development, deficiencies of which dramatically impact on postnatal neural function.
ISSN: 1471-2202
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group for Neurobiology and Gene Therapy
Vesalius Research Centre (-)
Laboratory for Biological Psychology
Molecular and Vascular Biology
× corresponding author
# (joint) last author

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