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Title: Efficient one-step synthesis of chiral bidentate oxazoline-alcohol ligands via a cyclic imidate ester rearrangement
Authors: Noel, Timothy ×
Robeyns, Koen
Van Meervelt, Luc
Van der Eycken, Erik
Van der Eycken, Johan #
Issue Date: Sep-2009
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron-asymmetry vol:20 issue:17 pages:1962-1968
Abstract: Various chiral bidentate oxazoline-alcohol ligands were obtained in a straightforward one-step synthesis via a cyclic imidate ester rearrangement. These chiral ligands were tested and compared in asymmetric diethylzinc additions to aldehydes resulting in selectivities of up to 87% ee. An interesting chirality switch was observed when a CPh2-tether instead of a CH2 was present, offering the opportunity for dual stereocontrol. (C) 2009 Elsevier Ltd. All rights reserved.
URI: 
ISSN: 0957-4166
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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