Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice
Nishida, Takefumi × De Yu, Jia Minamishima, Shizuka Sips, Patrick Y Searles, Robert J Buys, Emmanuel S Janssens, Stefan Brouckaert, Peter Bloch, Kenneth D Ichinose, Fumito #
Williams & Wilkins Co.
Critical Care Medicine vol:37 issue:1 pages:256-262
Objectives: Despite advances in resuscitation methods, survival after out-of-hospital cardiac arrest remains low, at least in part, due to postcardiac arrest circulatory and neurologic failure. To elucidate the role of nitric oxide (NO) in the recovery from cardiac arrest and cardiopulmonary resuscitation (CPR), we studied the impact of NO synthase (NOS3)/cGMP signaling on cardiac and neurologic outcomes after cardiac arrest and CPR.