Title: 11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid beta in Alzheimer's disease
Authors: Serdons, Kim ×
Verduyckt, Tom
Vanderghinste, Dominique
Borghgraef, Peter
Cleynhens, Jan
Van Leuven, Freddy
Kung, Hank
Bormans, Guy
Verbruggen, Alfons #
Issue Date: Apr-2009
Publisher: Elsevier france-editions scientifiques medicales elsevier
Series Title: European journal of medicinal chemistry vol:44 issue:4 pages:1415-1426
Abstract: Pittsburgh Compound-B (PIB) is currently being evaluated clinically for in vivo visualization of amyloid plaques in patients with Alzheimer's disease (AD). We have synthesized three structural isomers of 6-hydroxy-2-(4'-aminophenyl)-1,3-benzothiazole, performed radiolabelling with carbon-11 and investigated their in vivo and in vitro properties. Specific binding to amyloid plaques was demonstrated in vitro using post-mortem brain homogenates of AD patients, transgenic AD mice brain sections and postmortem human AD brain sections. In normal mice, initial brain uptake (at 2 min p.i.) was high and was followed by a fast wash-out. The three structural analogues have a high potential as tracer agents for in vivo visualization of amyloid plaques in AD patients. (C) 2008 Elsevier Masson SAS. All rights reserved.
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmaceutical Research
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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