Title: Application of proteomics in ovarian cancer: which sample should be used?
Authors: Cadron, Isabelle ×
Van Gorp, Toon
Timmerman, Dirk
Amant, Frédéric
Waelkens, Etienne
Vergote, Ignace #
Issue Date: Dec-2009
Publisher: Academic Press
Series Title: Gynecologic Oncology vol:115 issue:3 pages:497-503
Abstract: OBJECTIVE: In the last decade several studies have been published using proteomics to unravel molecular pathways and to find biomarkers which can be used for diagnosis and/or prognostication in ovarian cancer. This review gives an overview of proteomic studies performed in ovarian cancer focusing on the nature of samples that have been used. METHODS: Recent literature regarding the role of proteomic studies in ovarian cancer has been reviewed. RESULTS: Most studies have focused on finding biomarkers for early diagnosis of ovarian cancer using blood samples though proteins identified until now are mainly acute phase reactants. Studies regarding platinum sensitivity have only been performed on cell culture models and need confirmation in tissue samples. Proteomic studies using ovarian cancer tissue are sparse and mostly contain a low number of samples. CONCLUSION: To date no biomarkers for early diagnosis or prognostication in ovarian cancer have been found using proteomics. We speculate that it would be interesting to investigate the tissue proteome in an attempt to overcome acute phase reactants and to facilitate the discovery of real tumor-specific biomarkers instead of the identification of secondary protein changes.
ISSN: 0090-8258
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
Gynaecological Imaging Section (-)
Laboratory of Protein Phosphorylation and Proteomics
Laboratory of Phosphoproteomics (-)
× corresponding author
# (joint) last author

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