Title: Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions
Authors: Roncal, Carmen
Buysschaert, Ian
Gerdes, Norbert
Georgiadou, Maria
Ovchinnikova, Olga
Fischer, Christian
Stassen, Jean-Marie
Moons, Lieve
Collen, Desire
De Bock, Katrien
Hansson, Göran
Carmeliet, Peter # ×
Issue Date: Apr-2010
Publisher: British Medical Association
Series Title: Cardiovascular Research vol:86 issue:1 pages:29-36
Abstract: Aims: The vascular endothelial growth factor homologue placental growth factor (PlGF) is a
pleiotropic cytokine, with a pro-inflammatory activity. Previous gene-inactivation studies
revealed that loss of PlGF delays atherosclerotic lesion development and inhibits macrophage
infiltration, but the activity of an anti-PlGF antibody (aPlGF mAb) has not been evaluated yet.
Methods and Results: We characterized the potential of short-term delivery of aPlGF mAb in
inhibiting lesion development in ApoE-deficient mice (apoE-/-) and in CD4:TGFßRIIDN x apoE-/-
mice, a more severe atherosclerosis model. Short-term treatment of aPlGF mAb reduces
early atherosclerotic plaque size and inflammatory cell infiltration in the lesion.
Conclusions: These pharmacological aPlGF mAb results confirm previous genetic evidence
that inhibition of PlGF slows down early atherosclerotic lesion development. Furthermore, the
phenocopy of genetic and pharmacological loss-of-function strategies underscores that
aPlGF acts by selectively neutralizing PlGF.
ISSN: 0008-6363
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Animal Physiology and Neurobiology Section - miscellaneous
Molecular and Vascular Biology
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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