Title: Characterization of impurities in tobramycin by liquid chromatography-mass spectrometry
Authors: Li, Bo
Van Schepdael, Ann
Hoogmartens, Jos
Adams, Erwin # ×
Issue Date: May-2009
Publisher: Elsevier science bv
Series Title: Journal of chromatography a vol:1216 issue:18 pages:3941-3945
Abstract: The characterization of unknown impurities present in tobramycin by liquid chromatography (LC) coupled with mass spectrometry (MS) is described. A reversed-phase (RP)-LC method using a volatile mobile phase containing a perfluorinated ion-pair reagent was developed and coupled with an ion trap mass-spectrometer. The structures of the unknown impurities were deduced by comparison of their fragmentation patterns with those of the available reference substances obtained by LC-MSn experiments. (C) 2009 Elsevier B.V. All rights reserved.
ISSN: 0021-9673
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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