Title: High quality structure of cleaved PAI-1-stab
Authors: Dewilde, Maarten
Strelkov, Sergei
Rabijns, Anja
Declerck, Paul # ×
Issue Date: Feb-2009
Publisher: Academic Press
Series Title: Journal of Structural Biology vol:165 issue:2 pages:126-132
Abstract: Here we report the crystal structure of a stablilized plasminogen activator inhibitor-1 variant (PAI-1-N150H-K154T-Q301P-Q319L-M3541 (PAI-1-stab)) that shows a cleavage within the reactive centre loop. The new structure is of superior quality compared to the previously determined structure of the cleaved PAI-1-A335P mutant. We present a detailed comparison of the two structures and also compare them with the structure of the active PAI-1-stab. The structural data give important insights into the working mechanism of PAI-1 and also explain the role of various stabilizing mutations. (C) 2008 Elsevier Inc. All rights reserved.
ISSN: 1047-8477
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Pharmaceutical Biology (-)
Faculty of Pharmaceutical Sciences - miscellaneous
× corresponding author
# (joint) last author

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