Title: Renal cell carcinoma in 2009
Authors: Van Poppel, Hendrik # ×
Issue Date: 2009
Publisher: Ariez Medical Publishing
Series Title: Belgian Journal of Medical Oncology vol:3 issue:4 pages:145-152
Abstract: Summary
As radical nephrectomy for renal cell cancer
(RCC) will induce renal failure in a substantial
percentage of patients, nephron sparing
techniques were introduced many years ago in
imperative indications. While more experience
with this type of surgery was gained, nephron
sparing surgery was also applied in elective
indications i.e. in the presence of a normal
contralateral kidney. Nowadays, kidney sparing
surgery is also done in larger tumors, in more
central tumors and in more challenging surgical
situations. On the other hand, minimal invasive
techniques are gaining interest, with percutaneous
radiofrequency ablation and laparoscopic
cryotherapy being most frequently applied for
small renal masses. These techniques have
become developmental and because of their very
low morbidity and low cost they will certainly be
applied more and more often.
The use of targeted therapies with tyrosine kinase
inhibitors (TKIs), antibodies and m-TOR inhibitors
have given new hope to metastatic RCC patients
for whom in the past only aspecific immunotherapy
was available. Indications for the different
small molecules need to be regularly updated
depending on the results of the ongoing phase
III trials. There is certainly a need for further
investigation towards less toxic and more effective
drugs and combination treatments that could
substantially prolong patient survival.
(BJMO 2009;Vol 3;4:145-152)
ISSN: 1784-7141
Publication status: published
KU Leuven publication type: AT
Appears in Collections:Urology Section (-)
× corresponding author
# (joint) last author

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