Title: From mRNP trafficking to spine dysmorphogenesis: The roots of fragile X syndrome
Authors: Bagni, Claudia ×
Greenough, WT #
Issue Date: May-2005
Publisher: Nature publishing group
Series Title: Nature reviews neuroscience vol:6 issue:5 pages:376-387
Abstract: The mental retardation protein FMRP is involved in the transport of mRNAs and their translation at synapses. Patients with fragile X syndrome, in whom FMRP is absent or mutated, show deficits in learning and memory that might reflect impairments in the translational regulation of a subset of neuronal mRNAs. The study of FMRP provides important insights into the regulation and functions of local protein synthesis in the neuronal periphery, and increases our understanding of how these functions can produce specific effects at individual synapses.
ISSN: 1471-003X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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