Title: mRNPs, polysomes or granules: FMRP in neuronal protein synthesis
Authors: Zalfa, Francesca ×
Achsel, Tilmann
Bagni, Claudia #
Issue Date: Jun-2006
Publisher: Current biology ltd
Series Title: Current opinion in neurobiology vol:16 issue:3 pages:265-269
Abstract: mRNA localization and regulated translation play central roles in neurite outgrowth and synaptic plasticity. A key molecule in these processes is the Fragile X mental retardation protein, FMRP, which is involved in the metabolism of neuronal mRNAs. Absence or mutation of FMRP leads to spine dysmorphogenesis and impairs synaptic plasticity. Studies that have mainly been performed on the mouse and Drosophila models for Fragile X Syndrome showed that FMRP is involved in translational regulation at synapses, but even 15 years after discovery of the FMR1 gene, the precise working mechanisms remain elusive.
ISSN: 0959-4388
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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