Title: A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability
Authors: Zalfa, Francesca ×
Eleuteri, Boris
Dickson, Kirsten S
Mercaldo, Valentina
De Rubeis, Silvia
di Penta, Alessandra
Tabolacci, Elisabetta
Chiurazzi, Pietro
Neri, Giovanni
Grant, Seth G. N
Bagni, Claudia #
Issue Date: May-2007
Publisher: Nature publishing group
Series Title: Nature neuroscience vol:10 issue:5 pages:578-587
Abstract: Fragile X syndrome ( FXS) results from the loss of the fragile X mental retardation protein ( FMRP), an RNA- binding protein that regulates a variety of cytoplasmic mRNAs. FMRP regulates mRNA translation and may be important in mRNA localization to dendrites. We report a third cytoplasmic regulatory function for FMRP: control of mRNA stability. In mice, we found that FMRP binds, in vivo, the mRNA encoding PSD- 95, a key molecule that regulates neuronal synaptic signaling and learning. This interaction occurs through the 3' untranslated region of the PSD- 95 ( also known as Dlg4) mRNA, increasing message stability. Moreover, stabilization is further increased by mGluR activation. Although we also found that the PSD- 95 mRNA is synaptically localized in vivo, localization occurs independently of FMRP. Through our functional analysis of this FMRP target we provide evidence that dysregulation of mRNA stability may contribute to the cognitive impairments in individuals with FXS.
ISSN: 1097-6256
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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