Annual Meeting of the Society for Neuroscience edition:37 location:San Diego, CA, U.S.A. date:November 3-7, 2007
In cat, we have shown before that binocular deprivation by mask rearing induces morphological changes specifically in the Y-type large retinal ganglion cell population of the retina (Burnat 2004a, 2006a), which are mirrored by disturbed global motion perception as assessed behaviorally (Burnat et al., 2004b, 2006b). We here examined whether protein expression changes occur in typical X-, Y- or W-driven visual structures: the retinal targets, the dorsal lateral geniculate nucleus (dLGN: X+Y) and the superior colliculus (SC: Y+W), and visual areas 17 (X), 19 (W) and PMLS (Y). Four adult cats, binocularly deprived throughout the first 6 months of life, and 4 control cats were examined after several months of visual training (the same animals from which retinal and behavioral data were collected). A functional proteomics approach was applied for protein expression profiling. Using three-color 2-D DIGE, we have clearly identified the largest change in the expression profile of W-driven area 19. Although the Y pathway deficit induced changes in Y-driven visual structures, we propose that the W pathway, unaffected by binocular deprivation due to prenatal maturation, compensates for the Y pathway deficit, thereby rearranging the area 19 protein content.