Title: Acute encephalitis, a poliomyelitis-like syndrome and neurological sequelae in a hamster model for flavivirus infections
Authors: Leyssen, Pieter
Croes, Romaric
Rau, Philipp
Heiland, Sabine
Verbeken, Eric
Sciot, Raphael
Paeshuyse, Jan
Charlier, Nathalie
De Clercq, Erik
Meyding-Lamadé, Uta
Neyts, Johan # ×
Issue Date: Jul-2003
Publisher: International Society of Neuropathology
Series Title: Brain pathology vol:13 issue:3 pages:279-90
Abstract: Infection of hamsters with the murine flavivirus Modoc results in (meningo)encephalitis, which is, during the acute phase, frequently associated with flaccid paralysis, as also observed in patients with West Nile virus encephalitis. Twenty percent of the hamsters that recover from the acute encephalitis develop life-long neurological sequelae, reminiscent of those observed, for example, in survivors of Japanese encephalitis. Magnetic resonance imaging and histology revealed severe lesions predominantly located in the olfactory-limbic system, both in hamsters with acute encephalitis as in survivors. Prominent pathology was also detected in the spinal cord of hamsters with paralysis. Modoc virus infections in hamsters provide a unique model for the study of encephalitis, a poliomyelitis-like syndrome and neurological sequelae following flavivirus infection.
ISSN: 1015-6305
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Translational Cell & Tissue Research
Faculty of Pharmaceutical Sciences - miscellaneous
Department of Pharmaceutical & Pharmacological Sciences - miscellaneous
× corresponding author
# (joint) last author

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