Title: Arealization of cat visual system based on neurofilament protein distribution as revealed with the SMI-32 antibody
Authors: Van der Gucht, Estel
Vandesande, Frans
Arckens, Lut #
Issue Date: Nov-2001
Host Document: Soc. Neurosci. Abstr., 2001 vol:27
Conference: Annual Meeting of the Society for Neuroscience edition:31 location:San Diego, U.S.A. date:November 10-15, 2001
Article number: 619.27
Abstract: In this immunocytochemical study, we examined neurofilament protein staining in cat visual system using SMI-32. This antibody labels primarily the cell body and dendrites of pyramidal neurons in cortical layers III, V and VI. Neurofilament protein-immunoreactive neurons were prominent in twenty visual areas: areas 17, 18, 19, 20a, 20b, 21a, 21b, 7, posteromedial lateral, posterolateral lateral, anteromedial lateral, anterolateral lateral, dorsal lateral, ventral lateral and posterior suprasylvian areas, the anterior ectosylvian, the splenial, the cingulate and insular visual areas and the anterolateral gyrus area. We have also found strong immunopositive cells in the lateral geniculate nucleus complex (dLGN, MIN), but no cells were present in the vLGN, the PGN or the parvocellular C (1-3) laminae. In each cortical area, the SMI-32 antibody against neurofilament protein revealed a characteristic pattern of immunostaining: size, shape, intensity and density of neurofilament protein-immunoreactive neurons and their dendritic arborization differed substantially across all visual areas. Moreover, it was also obvious that several visual areas showed differences in laminar distribution. Those diverse profiles may be used to delineate various cortical areas. Therefore, the expression of neurofilament protein can be used as a specific marker to define areal patterns and topographic boundaries in cat visual system.
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
# (joint) last author

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