Title: Transition from stress sensitivity to a depressive state: longitudinal twin study
Authors: Wichers, Marieke ×
Geschwind, Nicole
Jacobs, Nele
Kenis, Gunter
Peeters, Frenk
Derom, Cathérine
Thiery, Evert
Delespaul, Philippe
van Os, Jim #
Issue Date: Dec-2009
Publisher: Royal Medico-Psychological Association
Series Title: British Journal of Psychiatry vol:195 issue:6 pages:498-503
Abstract: BACKGROUND: Daily-life stress sensitivity is associated with depression, but prospective data are lacking. AIMS: To examine associations between baseline ecological daily-life stress sensitivity and later depression, and to identify genetic and non-genetic factors moderating the transition from stress sensitivity to depression. METHOD: Daily-life stress sensitivity was assessed at baseline in twins (n = 502). One baseline and four follow-up measurements of depressive symptoms and negative life events were collected, as well as interview-based diagnoses at baseline and last follow-up. Hypothesised genetic markers were determined. RESULTS: Baseline stress sensitivity was associated with increased depressive symptoms at follow-up and risk of major depressive disorder. Both genetic liability and major life events moderated the probability of transition from stress sensitivity to depression. CONCLUSIONS: Onset of depression is attributable to pre-onset ecological measurements of stress sensitivity, particularly where genetic liability is high and individuals have reached a stage where the influence of competing environmental causes is low.
ISSN: 0007-1250
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Clinical Genetics
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Wichers.pdfpublisher's version pdf Published 115KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science