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Title: Interferons, interferon inducers, and interferon-ribavirin in treatment of flavivirus-induced encephalitis in mice
Authors: Leyssen, Pieter
Drosten, Christian
Paning, Marcus
Charlier, Nathalie
Paeshuyse, Jan
De Clercq, Erik
Neyts, Johan # ×
Issue Date: Feb-2003
Series Title: Antimicrobial Agents and Chemotherapy vol:47 issue:2 pages:777-82
Abstract: We evaluated the prophylactic and therapeutic efficacy of interferon alpha-2b, pegylated interferon alpha-2b, poly(I. C), and Ampligen against Modoc virus encephalitis in an animal model for flavivirus infections. All compounds significantly delayed virus-induced morbidity (paralysis) and mortality (due to progressive encephalitis). Viral load (as measured on day 7 postinfection) was significantly reduced by 80 to 100% in the serum, brain, and spleen in mice that had been treated with either interferon alpha-2b, pegylated interferon alpha-2b, poly(I. C), or Ampligen. We also studied whether a combination of interferon alpha-2b and ribavirin (presently the standard therapy for the treatment of infections with hepatitis C virus) would be more effective than treatment with interferon alone. However, ribavirin did not enhance the inhibitory effect of interferon therapy in this animal model for flavivirus infections.
URI: 
ISSN: 0066-4804
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Faculty of Pharmaceutical Sciences - miscellaneous
Department of Pharmaceutical & Pharmacological Sciences - miscellaneous
× corresponding author
# (joint) last author

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