Title: Vitamin D and 1,25-dihydroxyvitamin D3 as modulators in the immune system
Authors: Mathieu, Chantal
van Etten, Evelyne
Decallonne, Brigitte
Giulietti, Annapaula
Gysemans, Conny
Bouillon, Roger
Overbergh, Lutgart # ×
Issue Date: 6-Jun-2004
Publisher: Pergamon Press
Series Title: Journal of Steroid Biochemistry and Molecular Biology vol:89-90 issue:1-5 pages:449-52
Abstract: Treatment from weaning until old age with 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) prevents diabetes in NOD mice. It is mainly through its actions on dendritic cells (DCs), that 1,25(OH)(2)D(3) changes the function of potentially autoreactive T lymphocytes. In contrast, early life treatment (from 3 to 70 days of age) of NOD mice with vitamin D or 1,25(OH)(2)D(3) did not influence final diabetes incidence at 200 days of age. Also in spontaneous diabetic BB rats, diabetes could not be prevented by early life treatment (from 3 to 50 days of age) with vitamin D (1000 IU per day) or 1,25(OH)(2)D(3) (0.2 microg/kg per day or 1 microg/kg per 2 days). However, when NOD mice were made vitamin D deficient in early life (until 100 days of age), diabetes onset occurred earlier and final incidence was increased. These data further support a role for vitamin D and its metabolites in the pathogenesis of type 1 diabetes in NOD mice.
ISSN: 0960-0760
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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