Title: Renal effects of cadmium body burden of the general population
Authors: Buchet, JP ×
Lauwerys, R
Roels, H
Bernard, A
Bruaux, P
Claeys, F
Ducoffre, G
De Plaen, P
Staessen, Jan A
Amery, A
Lijnen, Paul
Thijs, Lutgarde
Rondia, D
Sartor, F
Saint-Remy, A
Nick, L #
Issue Date: 1990
Publisher: The Lancet Publishing Group
Series Title: The Lancet vol:336 pages:699-702
Abstract: In a cross-sectional population study to assess whether environmental exposure to cadmium is associated with renal dysfunction, 1699 subjects aged 20-80 years were studied as a random sample of four areas of Belgium with varying degrees of cadmium pollution. After standardisation for several possible confounding factors, five variables (urinary excretion of retinol-binding protein, N-acetyl-beta-glucosaminidase, beta 2-microglobulin, aminoacids, and calcium) were significantly associated with the urinary excretion of cadmium (as a marker of cadmium body burden), suggesting the presence of tubular dysfunction. There was a 10% probability of values of these variables being abnormal when cadmium excretion exceeded 2-4 micrograms/24 h. Excretion reached this threshold in 10% of non-smokers. There was also evidence that diabetic patients may be more susceptible to the toxic effect of cadmium on the renal proximal tubule.
ISSN: 0140-6736
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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