Acta Neurologica Belgica. Program and Abstract Book. pages:41
Bi-Annual Meeting of the Belgian Society for Neuroscience edition:8 location:Liège date:11 May 2009
Lately, the mouse has become a popular animal model to study visual system plasticity, mainly because of the opportunities that come with the application of genetically modified animals to further our understanding of the molecular mechanisms of brain plasticity. Also, the recent identification of functional subdivisions within the different visual areas of the mouse brain has paved the way to investigate the effect of small retinal lesions on mouse visual system.
Adult mice received a 15° lesion in the lower monocular visual field of the right retina through photo-coagulation. In situ hybridization studies for the activity markers zif268 and arc on frontal brain sections upon different survival times, ranging from 1 day to 8 weeks, revealed a discrete cortical inactive zone in the monocular segment of V1 that regained responsiveness over a period of 2-3 weeks. Subcortically however, in the superior colliculus, the activity pattern remained decreased, even after 8 weeks. Additional in situ hybridizations for GFAP showed how gliosis might be preventing proper functional recovery in this subcortical area. Our data substantiate a swift cortically mediated recovery of activity in adult mouse visual cortex upon sensory deprivation.