Title: Synthesis of 3 '-o-phosphonoethyl nucleosides with an adenine and a thymine base moiety
Authors: Huang, Qiuya
Herdewijn, Piet # ×
Issue Date: May-2009
Publisher: Taylor & francis inc
Series Title: Nucleosides nucleotides & nucleic acids vol:28 issue:5-7 pages:337-351
Abstract: The synthesis and antiviral evaluation of new 3'-O-phosphonoethyl modified phosphonate nucleosides related to PMDTA and PMDTT is described. The reaction scheme starts from protected L-threose and the phosphonate group is introduced by the Arbuzov reaction. The Z-OH as well as the Z-deoxygenated nucleosides have been obtained. Unfortunately, none of these synthesized compounds shows activity against HIV and HCV
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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