Title: Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines
Authors: Karki, Subhas ×
Hazare, Rahul
Kumar, Sujeet
Bhadauria, Vivek
Balzarini, Jan
De Clercq, Erik #
Issue Date: Dec-2009
Publisher: Croatian Pharmaceutical Society
Series Title: Acta Pharmaceutica vol:59 issue:4 pages:431-440
Abstract: Various 6-aralkyl-9-substituted-6H-indolo[2,3-b]quinoxalines were synthesized by reaction of 1,5-disubstituted 2,3-dioxo-2,3-dihydroindole and orthophenylene diamine. Appreciable anticancer activity of compounds 5b, 5d, 5g and 5l at various cell lines among 59 human tumor cell panels was observed. All the synthesized compounds were evaluated for cytostatic activity against human Molt 4/C8 and CEM T-lymphocytes as well as for murine L1210 leukemia cells. Compound 5h exhibited an I C50 of 23 mumol L-1 against Molt 4/C8 and 38 mumol L-1 against CEM compared to melphalan 3.2 mumol L-1 and 2.5 mumol L-1, respectively. The I C50 for compound 7i against L1210 was 7.2 mumol L-1 compared to melphalan 2.1 mumol L-1.
ISSN: 1330-0075
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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