Acta Neurologica Belgica. Program and Abstract Book pages:39
Bi-Annual Meeting of the Belgian Society for Neuroscience edition:8 location:Liège date:11 May 2009
Very little is known about information processing in mouse visual cortex. We report the results of extracellular single-unit recordings where we quantitatively analyzed the receptive-field (RF) properties of neurons in V1 and adjacent extrastriate visual areas of anesthetized mice with emphasis on revealing their RF center-surround organization. Drifting sine-wave gratings were used to analyze neuron’s selectivity for stimulus orientation, spatial (SF) and temporal frequency (TF), contrast sensitivity, and size. When species differences in spatial scale are taken into consideration, visual cortical neurons in mice have remarkably fine stimulus selectivity and the RF center-surround organization is similar to that in macaque monkeys (i.e. a RF center surrounded by extended suppressive regions). Unlike in higher mammals, however, a significant proportion of cortical neurons did not exhibit quantifiable RF surround suppression. Simple cells had smaller RF centers than complex cells, and the prevalence and strength of surround suppression were far greater in simple cells than in complex cells. These findings, particularly on the RF center-surround organization of visual cortical neurons, give new insights into the principles governing cortical circuits in mouse visual brain.